TOPping up ATR Activity
نویسندگان
چکیده
The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.
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ورودعنوان ژورنال:
- Cell
دوره 124 شماره
صفحات -
تاریخ انتشار 2006